HEXAMETHYLENEIMINOACETONITRILE synthesis
- Product Name:HEXAMETHYLENEIMINOACETONITRILE
- CAS Number:54714-50-0
- Molecular formula:C8H14N2
- Molecular Weight:138.21
Yield:54714-50-0 92%
Reaction Conditions:
in water at 5 - 70; for 0.5 h;
Steps:
184
1-Azepanylacetonitrile (290). Azepane (289) (4.9 ml_, 43.8 mmol) was added dropwise to a stirred aqueous solution of glycolonitrile (55%, 5.0 g, 48.2 mmol) at 5 0C and the solution was stirred at 70 0C for 30 min. The solution was cooled, diluted with water (20 mL), washed with Et2O (3 x 50 ml_). The organic fraction was dried and the solvent evaporated to give nitrile 290 (5.58 g, 92%) as a colourless oil: 1H NMR δ 3.56 (s, 2 H, CH2CN), 2.71 (br dd, J = 5.8, 5.5 Hz, 4 H, 2 x CH2N), 1.67-1.73 (m, 4 H, 2 x CH2), 1.59- 1.64 (m, 4 H, 2 x CH2).
References:
WO2006/104406,2006,A1 Location in patent:Page/Page column 168
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