Ethyl 3-methyl-1H-pyrazole-5-carboxylate synthesis
- Product Name:Ethyl 3-methyl-1H-pyrazole-5-carboxylate
- CAS Number:4027-57-0
- Molecular formula:C7H10N2O2
- Molecular Weight:154.17
615-79-2
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$8.00/5g
4027-57-0
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$6.00/1g
Yield:4027-57-0 97%
Reaction Conditions:
with hydrazine hydrate in ethanol at 0; for 1 h;
Steps:
Preparation of ethyl 3-methyl-1 H-pyrazole-5-carboxylate
A solution of ethyl 2,4-dioxopentanoate (20 g, 1 26 mmol, 18 mL) and hydrazine hydrate (6.96 g, 139 mmol, 6.76 mL) in ethanol (400 mL) was stirred at 0°C for 1 hour. The mixture was concentrated to give ethyl 3-methyl-1 H-pyrazole-5-carboxylate (19 g, 1 23 mmol, 97% yield).
References:
H. LUNDBECK A/S;KEHLER, Jan;JUHL, Karsten;MARIGO, Mauro;VITAL, Paulo, Jorge, Vieira;JESSING, Mikkel;LANGG?RD, Morten;RASMUSSEN, Lars, Kyhn;CLEMENTSON, Carl, Martin, Sebastian WO2018/7249, 2018, A1 Location in patent:Page/Page column 75
