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ChemicalBook CAS DataBase List ADIPIC ACID MONOBENZYL ESTER
40542-90-3

ADIPIC ACID MONOBENZYL ESTER synthesis

9synthesis methods
-

Yield: 87%

Reaction Conditions:

with DOWEX 50W-X2 in octane at 100; for 4 h;Heating / reflux;

Steps:

12
DOWEX 50W-X2 (2 g), benzyl formate (10 mL, mol), and adipic acid (2 g, mol) were added to octane (10 mL). The mixture was refluxed for 4 hours at 100° C., and the crude product was purified via silica chromatography to yield a clear, colorless liquid (87% yield). 1H NMR (CDCl3) 1.59-1.78 (m, 4H, CH2CH2), 2.33-2.39 (m, 4H, CH2COOH), 5.09 (s, 2H, PhCH2), 7.25-7.30 (m, 5H, aromatic).

References:

Colson, Yolonda;Azouz, Solomon;Grinstaff, Mark;Wolinsky, Jesse;Griset, Aaron US2008/75718, 2008, A1 Location in patent:Page/Page column 41

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