ADIPIC ANHYDRIDE synthesis
- Product Name:ADIPIC ANHYDRIDE
- CAS Number:2035-75-8
- Molecular formula:C6H8O3
- Molecular Weight:128.13
124-04-9
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2035-75-8
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Yield:2035-75-8 82.5%
Reaction Conditions:
Stage #1:Adipic acid with acetic anhydride at 160; for 4 h;
Stage #2:zinc diacetate at 100 - 200;
Steps:
33
Adipic acid (96.28 g, 0.6588mol) and acetic anhydride (400 mL) were combined and refluxed at 160 0C for four hours. Afterwards, the acetic acid/anhydride was removed under vacuum. Next the depolymerization catalyst, zinc acetate monohydrate, was added along with a distillation apparatus and the heat was slowly increased. After 100 0C, nothing was collected until 200 0C when 68.79 g of a clear colorless liquid was collected (82.5 % yield). 1H NMR (400 MHz, CDCl3): δ 1.91 (m, 4, - CH2-CH2-CH2-CH2-), 2.67 (m, 4, -CH2-CH2-CH2-CH2-). 13C NMR (100.6 MHz, CDCl3): δ 168.38 (-COOCO-), 34.60 (CH2), 22.37 (CH2). GC-MS 128 m/z [M]+ (Theory: 128.12 m/z [M]+).
References:
HYPERBRANCH MEDICAL TECHNOLOGY, INC. WO2006/31388, 2006, A2 Location in patent:Page/Page column 238-239
108-94-1
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502-44-3
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2035-75-8
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627-93-0
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629-11-8
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2035-75-8
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627-93-0
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1191-25-9
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627-91-8
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2035-75-8
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502-44-3
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2035-75-8
143 suppliers
$45.00/50mg