6-CHLORO-1-TRIMETHYLSILYLOXYHEXANE synthesis
- Product Name:6-CHLORO-1-TRIMETHYLSILYLOXYHEXANE
- CAS Number:34714-00-6
- Molecular formula:C9H21ClOSi
- Molecular Weight:208.8
Yield:34714-00-6 98.6%
Reaction Conditions:
with triethylamine in ethyl acetate at 0 - 10; for 8 h;Green chemistry;Temperature;
Steps:
1.C; 2.C Intermediate C:
In a 1000 L dry clean enamel reactor, the metered 6-chlorohexanol is:150kg, ethyl acetate: 400kg, triethylamine: 125kg input, stir and cool to 0 ° C, add 145kg of trimethylchlorosilane, control the temperature at 0 ° C, the end of the addition, stir and keep 5 ° C, 8 hours,The detection and control of 6-chlorohexanol is less than 0.5%, the reaction is finished, 200kg of water is added, stirred for 30min, static layering, the water layer is separated, and the organic layer is concentrated under negative pressure until the solvent is not.6-chlorohexanol trimethylsilyl ester was obtained, and the GC detection content was 97.25%. The amount of liquid is: 218.6kg,The yield was 98.6%.
References:
CN110078593,2019,A Location in patent:Paragraph 0030; 0035; 0036; 0039; 0044; 0045
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