6-bromo-4-methylquinazoline synthesis
- Product Name:6-bromo-4-methylquinazoline
- CAS Number:69674-27-7
- Molecular formula:C9H7BrN2
- Molecular Weight:223.07
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Yield: 83%
Reaction Conditions:
with ammonium acetate at 100;
Steps:
1.1 Step 1: Preparation of 6-bromo-4-methylquinazoline
Add 1-(2-amino-5-bromophenyl)ethanone (3g, 14mmol), triethyl orthoformate (3.1g, 21mmol) and ammonium acetate (1.62g, 21mmol) into the reaction flask at 100°C React overnight.After the reaction was completed, it was cooled to room temperature, and the reaction solution was concentrated. The residue was diluted with water and extracted with ethyl acetate.The organic phases were combined, dried over anhydrous sodium sulfate, and filtered.The filtrate was concentrated, and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether = 1/3) to obtain the title compound of this step (2.6 g, yield: 83%).
References:
Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.;Liu Jinming;He Ting;Cai Jiaqiang;Kang Xiwei;Wang Lichun;Wang Jingyi CN111377906, 2020, A Location in patent:Paragraph 0240; 0241; 0242-0244
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