5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine synthesis
- Product Name:5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
- CAS Number:1010120-55-4
- Molecular formula:C6H5BrN4
- Molecular Weight:213.03
![5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine](/NewsImg/2023-10-31/6383436521043138765517717.jpg "5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine")
1010120-59-8
22 suppliers
$195.00/1g
1010120-55-4
163 suppliers
$6.00/100mg
Yield:1010120-55-4 92.8%
Reaction Conditions:
with hydroxylamine hydrochloride;triethylamine in ethanol at 70 - 100; for 3 h;
Steps:
1.2 Step 2 Synthesis of 5-bromo- [1,2,4] triazolo [1,5-a] pyridin-2-amine (IV)
At room temperature, 41.4 g (0.60 mol) of hydroxylamine hydrochloride and 60.6 g (0.60 mol) of triethylamine were added to 450 mL of ethanol, stirred for 1 h, 90.9 g (0.30 mol) of intermediate II was added to the reaction solution, 70-100 ° C After 3 hours of reaction, the reaction was completed, the reaction solution was concentrated, cooled, and a white solid precipitated, which was filtered with suction. The filter cake was rinsed with water (100 mL × 2) and cold ethanol (100 mL).After drying, 59.1 g of white crystals were obtained, and the total yield was 92.8%.
References:
CN111072655,2020,A Location in patent:Paragraph 0046; 0059; 0062-0063
19798-81-3
438 suppliers
$5.00/1g
1010120-55-4
163 suppliers
$6.00/100mg