ChemicalBook CAS DataBase List 2-Amino-6-bromopyridine

2-Amino-6-bromopyridine synthesis

13synthesis methods

Product Name:2-Amino-6-bromopyridine
CAS Number:19798-81-3
Molecular formula:C5H5BrN2
Molecular Weight:173.01

144100-07-2 Synthesis

144100-07-2
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$10.00/5g

19798-81-3
438 suppliers
$5.00/1g

Yield:19798-81-3 93%

Reaction Conditions:

with pentanamidine hydrochloride;sodium t-butanolate in diethylene glycol dimethyl ether;water at 150; for 24 h;

Steps:

7 preparation of 6-bromo-2-amino-pyridine

2-fluoro-6-bromo-pyridine (1 mmol) was added to a 25 ml reaction tube.Pentamidine hydrochloride (2mmol), sodium tert-butoxide (3mmol),H2O (0.5 mL) and diethylene glycol dimethyl ether (2.5 mL).The reaction is carried out at 150 ° C for a reaction time of 24 hours.Cool to room temperature.The reaction was quenched by adding 10 mL of ethyl acetate, and washed with 6 mL of saturated brine.The organic phase was separated, and the aqueous phase was extracted three times with ethyl acetate (ethyl acetate (6 mL)).The solvent is distilled off under reduced pressure, including an organic solvent and an inorganic solvent, the organic solvent,The title product was isolated by column chromatography, yield 93%.

References:

CN109232402,2019,A Location in patent:Paragraph 0061; 0062

626-05-1 Synthesis