2-Amino-5-bromothiazole synthesis
- Product Name:2-Amino-5-bromothiazole
- CAS Number:3034-22-8
- Molecular formula:C3H3BrN2S
- Molecular Weight:179.04
96-50-4
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$5.00/5g
3034-22-8
203 suppliers
$7.00/250mg
Yield:3034-22-8 75%
Reaction Conditions:
with bromine;acetic acid at 0 - 30; for 2 h;
Steps:
5.a
(a)at 0 ° C2-Aminothiazole (400 mg, 4 mmol) was dissolved in 16 mLAcetic acid solution,Bromine (408 μL, 8 mmol) was slowly added dropwise.The mixture was further stirred at room temperature for 2 hours,TLC reaction was monitored until the reaction was completed,The pH was adjusted to 7-8 with saturated NaHCO3,Ethyl acetate (20 mL x 3), washed with saturated saline and the organic layer was mixed,Dry over anhydrous sodium sulfate, filter and concentrate and purify by column chromatography5-Bromothiazol-2-amine(520 mg, 75% yield).
References:
Chinese Academy Of Sciences Shanghai Organic Chemistry Institute;Zhu Jidong;Gu Shoulai;Si Xiaojia;Xie Jingjing;Shen Jian CN107286150, 2017, A Location in patent:Paragraph 0354; 0355; 0356
61296-22-8
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$6.00/1g
3034-22-8
203 suppliers
$7.00/250mg
7336-54-1
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$45.00/250 mg
3034-22-8
203 suppliers
$7.00/250mg
3034-56-8
68 suppliers
$32.00/250mg
3034-22-8
203 suppliers
$7.00/250mg
226879-69-2
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3034-22-8
203 suppliers
$7.00/250mg
108-95-2
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$14.00/25g