5-Azacytosine synthesis
- Product Name:5-Azacytosine
- CAS Number:931-86-2
- Molecular formula:C3H4N4O
- Molecular Weight:112.09
Yield:931-86-2 75%
Reaction Conditions:
at 115; for 2 h;
Steps:
2.1; 2.2 Example 2
(1)Weigh 42 g (0.5 mol) of dicyandiamide in a dry reaction kettle.100 mL (1.25 mol) of ethyl formate was added to the reaction kettle and mixed with dicyandiamide.The reactor was placed in an oven and the temperature was raised to 115 ° C.After being kept for 120 minutes, it was taken out, and the liquid in the kettle was distilled off, and then cooled.The resulting white solid was taken out.(2)Transfer the white solid to a 1000 mL three-necked flask.200 mL of a 10% strength diluted hydrochloric acid was added.Heat to reflux for 30 minutes until the solution became clear, and the clear liquid was filtered while hot.Ammonia water was added to the filtrate to adjust the pH to 6, and white crystals were precipitated. After centrifugation,5-azacytosine can be obtained by drying in a hot air oven at 120 ° C42g(75% yield based on dicyandiamide).
References:
Taishan Medical School;Chen Hongyu;Li Ping;Sun Fanrong;Zhang Ximan CN109020907, 2018, A Location in patent:Paragraph 0032; 0033; 0034; 0035
