5-Amino-2,3-dichloropyridine synthesis
- Product Name:5-Amino-2,3-dichloropyridine
- CAS Number:98121-41-6
- Molecular formula:C5H4Cl2N2
- Molecular Weight:163
22353-40-8
248 suppliers
$6.00/1g
7439-89-6
453 suppliers
$10.00/25g
98121-41-6
198 suppliers
$8.00/250mg
Yield: 85%
Reaction Conditions:
with magnesium sulfate in water;acetic acid;ethyl acetate
Steps:
10 3-amino-5,6-dichloropyridine
EXAMPLE 10 3-amino-5,6-dichloropyridine 77.2 g (0.4 mol) of 2,3-dichloro-5-nitropyridine were dissolved in 135 ml of glacial acetic acid, and 800 ml of water were added with stirring. 111.7 g (2 mol) of iron powder were introduced in portions into the mixture (temperature≤50° C.). After completion of the reaction, the mixture is filtered under suction and the product extracted using ethyl acetate. The organic phase was washed with water until neutral, dried using MgSO4 and concentrated by evaporation. The product was recrystallized from toluene. Yield 85% Melting point 107° C.
References:
Hoechst Aktiengesellschaft US4756739, 1988, A
22353-40-8
248 suppliers
$6.00/1g
98121-41-6
198 suppliers
$8.00/250mg
22353-40-8
248 suppliers
$6.00/1g
98121-41-6
198 suppliers
$8.00/250mg
5418-51-9
457 suppliers
$12.72/1gm:
98121-41-6
198 suppliers
$8.00/250mg
22353-38-4
173 suppliers
$9.00/250mg
98121-41-6
198 suppliers
$8.00/250mg