3-Chloro-2-hydroxy-5-nitropyridine synthesis
- Product Name:3-Chloro-2-hydroxy-5-nitropyridine
- CAS Number:22353-38-4
- Molecular formula:C5H3ClN2O3
- Molecular Weight:174.54
5418-51-9
445 suppliers
$12.72/1gm:
22353-38-4
170 suppliers
$9.00/250mg
Yield: 96%
Reaction Conditions:
Stage #1:5-nitro-2-hydroxypyridine with hydrogenchloride at 20;
Stage #2: with sodium chlorate at 50; for 1 h;
Steps:
3.1.1. 2-Hydroxy-3-chloro-5-nitropyridine (2)
2-Hydroxy-5-nitropyridine (200 g, 1.42 mol) was added portion wise to 800 ml of concentrated HCl under constant stirring and then heated to 50 C. To this was slowly added a solution of sodium chlorate (80.0 g, 0.75 mol) inwater. The reactionwas maintained at the same temperature for an additional hour, and then cooled to 0 C. The precipitate obtainedwas filtered,washed thoroughly with water and dried to give 2-Hydroxy-3-chloro-5-nitropyridine. Yield: 240 g, 1.37 mmol (96.0%). M.P.: 195 e197 C. 1H NMR (300 MHz, DMSO-d6): d 8.65 (d, 1H, J ? 2.5 Hz), 8.36 (d, 1H, J ? 2.5 Hz). 13C NMR (300 MHz, DMSO-d6): d 153.40, 144.29, 143.59, 135.08, 130.44. MS (ES): 175 (M t H)t.
References:
Bajare, Swapnil;Anthony, Jessy;Nair, Amrutha;Marita, Rosalind;Damre, Anagha;Patel, Dharmeshkumar;Rao, Chandrika;Sivaramakrishnan;Deka, Nabajyoti [European Journal of Medicinal Chemistry,2012,vol. 58,p. 355 - 360]
89-73-6
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$14.00/5g
22353-40-8
249 suppliers
$6.00/1g
59-49-4
329 suppliers
$6.00/5g
22353-38-4
170 suppliers
$9.00/250mg
22353-40-8
249 suppliers
$6.00/1g
22353-38-4
170 suppliers
$9.00/250mg
22353-35-1
91 suppliers
$18.00/250mg
22353-38-4
170 suppliers
$9.00/250mg
4214-76-0
515 suppliers
$6.00/10g
22353-38-4
170 suppliers
$9.00/250mg