3-Aminopyridine synthesis
- Product Name:3-Aminopyridine
- CAS Number:462-08-8
- Molecular formula:C5H6N2
- Molecular Weight:94.11
16013-85-7
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$9.00/5g
462-08-8
472 suppliers
$14.00/25g
Yield:462-08-8 100 %Spectr.
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen;sodium hydrogencarbonate in methanol at 20; under 760.051 Torr; for 2 h;Sealed tube;chemoselective reaction;
Steps:
General procedure forhydrodechlorination of 2-chloropyridine derivatives
General procedure: To a solution of the 2-chloropyridine derivative (1 equiv.) in MeOH (10 mL) was added 10% Pd/C (1 mol%) and NaHCO3 (1 equiv. per pyridine chlorine).The reaction vessel was sealed and flushed with hydrogen gas three times. The black suspension was stirred at room temperature under an atmosphere of hydrogen (1 atm.) for two hours. The mixture was filtered through celite washing with methanol and concentrated in vacuo. Purification by column chromatography was performed as required to yield the hydrodechlorinated pyridine product.
References:
Kinarivala, Nihar;Trippier, Paul C. [Tetrahedron Letters,2014,vol. 55,# 39,p. 5386 - 5389] Location in patent:supporting information
5470-18-8
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462-08-8
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$14.00/25g
1120-90-7
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$5.00/250mg
462-08-8
472 suppliers
$14.00/25g
626-55-1
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$5.00/5/ G
462-08-8
472 suppliers
$14.00/25g
4548-45-2
545 suppliers
$6.00/5g
462-08-8
472 suppliers
$14.00/25g