ChemicalBook CAS DataBase List 4-Chloroaniline

4-Chloroaniline synthesis

13synthesis methods

Product Name:4-Chloroaniline
CAS Number:106-47-8
Molecular formula:C6H6ClN
Molecular Weight:127.57

synthesis of 4-Chloroaniline: p-chloronitrobenzene is used as raw material, Raney nickel is used as catalyst, ethanol is used as solvent, reaction temperature is 50～70°C , hydrogenation pressure is 3.04～3.55MPa, and medium pH=5～6 conditions, carry out Catalytic hydrogenation reaction to obtain 4-Chloroaniline.

1679-18-1 Synthesis

1679-18-1
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106-47-8
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Yield:106-47-8 92%

Reaction Conditions:

with potassium carbonate;ammonium hydroxide in methanol at 60; for 21 h;

Steps:

General procedure for the synthesis of primary amines

General procedure: RGO/Cu NPs (25 mg), arylboronic acid (1.0 mmol), K2CO3(1.3 mmol), 25-28% aqueous ammonia (5 mmol) and methanol(4 mL) were added to a 50 mL round-bottomed flask. The reactionmixture was stirred under reflux conditions for the appropriatetime. After completion of the reaction as monitored by TLC, themixture was filtered, and the solvent of the filtrate was removedunder vacuum with the aid of a rotary evaporator. The residue waspurified by column chromatography on silica gel to afford the prod-uct. All products are known in the literature and the physical data(mp, IR, NMR) of the products were found to be identical with thosereported in the literature [36,37].

References:

Fakhri, Parisa;Jaleh, Babak;Nasrollahzadeh, Mahmoud [Journal of Molecular Catalysis A: Chemical,2014,vol. 383-384,p. 17 - 22]