ChemicalBook CAS DataBase List 4-aminopentan-1-ol

4-aminopentan-1-ol synthesis

5synthesis methods

Product Name:4-aminopentan-1-ol
CAS Number:927-55-9
Molecular formula:C5H13NO
Molecular Weight:103.16

10312-37-5
2 suppliers
inquiry

927-55-9
37 suppliers
$145.00/100mg

Yield:927-55-9 58%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20;Inert atmosphere;

Steps:

50.2
[00370] To a solution of Example 50b (9 g, 55.9 mmol) in THF (160 mL) cooled to 0-5°C was slowly added LiAlH4 (7.4 g, 195.6 mmol). The mixture was stirred at r.t. overnight under N2. The reaction mixture was cooled to -10°C and quenched with H20 (7 mL), followed by aq. 15% NaOH (7 ml) and H20 (21 ml). The resulting mixture was stirred for 1 h and filtrated.The filtratewas concentrated to give the desired product Example 50c (3.3 g, yield 58%) as yellow oil. LCMS [M+l]+ = 104.1

References:

FRONTHERA U.S. PHARMACEUTICALS LLC;JIN, Bohan;DONG, Qing;HUNG, Gene WO2019/51265, 2019, A1 Location in patent:Paragraph 00370; 00369

FullText