3-Methyl-2-cyclohexen-1-one synthesis
- Product Name:3-Methyl-2-cyclohexen-1-one
- CAS Number:1193-18-6
- Molecular formula:C7H10O
- Molecular Weight:110.15
2396-63-6
108 suppliers
$24.00/1mL
1193-18-6
167 suppliers
$6.00/1g
Yield:1193-18-6 87%
Reaction Conditions:
with silver tetrafluoroborate;water in acetic acid at 110; for 10 h;regioselective reaction;
Steps:
24 4.2. General procedure for the synthesis of methyl ketones (2a-x). 4.2.24. 3-Methylcyclohex-2-enone (2x)
General procedure: To the mixture of terminal alkyne (1mmol), water (2.0 equiv), and acetic acid (2 mL), silver tetrafluoroborate (5 mol%) was added. The mixture was stirred at 110°C for 10 h. Water (10 mL) was added and the solution was extracted with ethyl acetate (3×8 mL), the combined extract was dried with anhydrous MgSO4. The solvent was removed and the crude product was separated by column chromatography to give the pure sample. 4.2.24. 3-Methylcyclohex-2-enone (2x). 1H NMR (400 MHz, CDCl3): δ=5.88 (s, 1H), 2.34 (t, J=6.8 Hz, 2H), 2.28 (t, J=6.4 Hz, 2H), 1.97-2.05 (m, 2H), 1.95 (s, 3H). 13C NMR (100 MHz, CDCl3): δ=199.9, 162.9, 126.6, 36.9, 30.9, 24.5, 22.5.
References:
Chen, Zheng-Wang;Ye, Dong-Nai;Qian, Yi-Ping;Ye, Min;Liu, Liang-Xian [Tetrahedron,2013,vol. 69,# 30,p. 6116 - 6120]
591-49-1
147 suppliers
$10.00/1g
1193-18-6
167 suppliers
$6.00/1g
21378-21-2
53 suppliers
$54.70/1g
1193-18-6
167 suppliers
$6.00/1g
591-49-1
147 suppliers
$10.00/1g
1193-18-6
167 suppliers
$6.00/1g
21378-21-2
53 suppliers
$54.70/1g
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1713-33-3
56 suppliers
$28.00/250mg
