3-(HEXYLAMINO)PROPIONITRILE synthesis
- Product Name:3-(HEXYLAMINO)PROPIONITRILE
- CAS Number:55490-85-2
- Molecular formula:C9H18N2
- Molecular Weight:154.25
111-26-2
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Yield: 80% ， 8%
Reaction Conditions:
in neat (no solvent) at 20; for 20 h;Green chemistry;Michael Addition;
Steps:
5.15 4.3 Procedure B: general procedure followed for the preparation of adducts 3, 5 and 6
General procedure: Amine (1) (10mmol) was added to dimethyl maleate (2) (10mmol), under stirring in a round bottomed flask equipped with a magnetic bar. The reaction was left stirring at ambient conditions and monitored by TLC and GC analysis. The resulting adduct (3) was purified by gravity column chromatography on silica gel, using mixtures of n-hexane and ethyl acetate, and dried by rotary evaporation. The yield was obtained and the product was then analysed by IR and NMR spectroscopy. For adducts 5 and 6 Procedure B was followed with the difference being that the Michael acceptor 4 was used instead of 2 together with 1-hexylamine (1k), while keeping all of the other conditions the same.
References:
Bosica, Giovanna;Debono, Anthony John [Tetrahedron,2014,vol. 70,# 37,p. 6607 - 6612]