3-Fluorophenylacetonitrile synthesis
- Product Name:3-Fluorophenylacetonitrile
- CAS Number:501-00-8
- Molecular formula:C8H6FN
- Molecular Weight:135.14
Yield:501-00-8 50%
Reaction Conditions:
in dimethyl sulfoxide at 30;
Steps:
8
A solution of compound 36-1 (1.0 g, 5.3 mmol) and NaCN (520 mg, 10.6 mmol) in DMSO (10 mL) was stirred at 30 0C overnight. TLC showed the reaction was completed. The mixture was diluted with water (30 mL), and extracted with ethyl acetate (50 mL). The organic layer was washed by water (10 mL x 5) and NaHCOs (sat., 20 mL), dried over anhydrous Na2SO4, and concentrated. The residue was purified by flash chromatography to give 36-2 as colorless oil (360 mg, yield: 50%).
References:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY;YUAN, Junying;MA, Dawei;LIU, Junli;ZHANG, Lihong WO2011/11522, 2011, A2 Location in patent:Page/Page column 57
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