3-FLUOROCATECHOL synthesis
- Product Name:3-FLUOROCATECHOL
- CAS Number:363-52-0
- Molecular formula:C6H5FO2
- Molecular Weight:128.1
28177-50-6
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$62.00/1g
363-52-0
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$7.00/250mg
Yield:363-52-0 78%
Reaction Conditions:
Stage #1: 2-fluoro-6-iodophenolwith potassium hydroxide;water for 8 h;Heating / reflux;
Stage #2: with hydrogenchloride;water at 20; pH=2 - 3;
Steps:
5.1
1) Synthesis of 3-fluorocatechol [H]: To a 500 ml flask were added 119 g (0.5 mol) of 2-fluoro-6-iodophenol and 200 ml of a 30% aqueous potassium hydroxide solution and they were reacted under vigorous stirring under a reflux temperature for 8 hours. After the termination of the reaction, the mixture was cooled to ordinary temperature and neutralized with hydrochloric acid to adjust pH between 2 and 3. After filtration, the filtrate was washed with water to obtain 49.9 g of a product [H]. The process yield was 78%.
References:
EP2055692,2009,A1 Location in patent:Page/Page column 9
367-12-4
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363-52-0
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$7.00/250mg
120-80-9
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363-52-0
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$7.00/250mg
699-92-3
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$54.00/250mg
363-52-0
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462-06-6
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$10.00/5g
363-52-0
206 suppliers
$7.00/250mg