Catechol synthesis
- Product Name:Catechol
- CAS Number:120-80-9
- Molecular formula:C6H6O2
- Molecular Weight:110.11
90-05-1
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120-80-9
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Yield:120-80-9 99%
Reaction Conditions:
Stage #1: 2-methoxy-phenolwith pyridine;iodine;aluminium in acetonitrile; for 18 h;Reflux;
Stage #2: with hydrogenchloride in lithium hydroxide monohydrate;acetonitrile at 20;
Steps:
14 Example 14 (guaiacol demethylation)
To a 100 ml eggplant flask were added iodine (2.098 g), aluminum powder (0.467 g) and acetonitrile (50 ml), heated toReflux, stir for 2 hours to the purple red of iodine disappears. Then pyridine (1.889 g) and guaiacol (0.621 g) were added to continue the reaction18 hours. After stirring at room temperature, 2 mol / L dilute hydrochloric acid (10 ml) was added to the reaction solution, and the mixture was extracted with ethyl acetate(50 ml x 3). The organic phases were combined and dried over anhydrous sodium sulfate. The filtrate was evaporated to dryness with a rotary evaporator and the residue passed throughPurified column chromatography (mobile phase ethyl acetate: petroleum ether = 1: 1, volume ratio) to obtain catechol (colorless needleCrystal, 0.546 g, yield 99%).
References:
CN106278825,2017,A Location in patent:Paragraph 0077; 0078; 0079
89466-08-0
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120-80-9
519 suppliers
$13.00/25g
94-71-3
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120-80-9
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4812-20-8
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120-80-9
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533-58-4
373 suppliers
$6.00/5g
120-80-9
519 suppliers
$13.00/25g