3-Aminoisonicotinic acid synthesis
- Product Name:3-Aminoisonicotinic acid
- CAS Number:7579-20-6
- Molecular formula:C6H6N2O2
- Molecular Weight:138.12
13959-02-9
342 suppliers
$5.00/1g
7579-20-6
273 suppliers
$10.00/1g
Yield:7579-20-6 95.2%
Reaction Conditions:
with ammonium hydroxide;copper(l) iodide at 100 - 105; for 8 h;Autoclave;Time;
Steps:
1.2; 2.2; 3.2 2. Synthesis of 3-amino-4 pyridinecarboxylic acid
50g (0.25mol) of 3-bromo-4-pyridinecarboxylic acid was added in batches to 125ml of 18% ammonia water, 1.44g (0.0075mol) of cuprous iodide was added, and the temperature was closed in an autoclave to 100-105°C and stirred for reaction 8 Hours, cooled to room temperature, adjusted the pH to 5.5-6 with 26% hydrochloric acid, filtered and dried to obtain 32.9g of 3-amino-4pyridinecarboxylic acid, yield 95.2%, HPLC purity 99.7%
References:
Suzhou Chenghe Pharmaceutical And Chemical Co., Ltd.;Chen Xiaoqiang CN111018775, 2020, A Location in patent:Sheet 0013; 0015; 0016; 0019;0020; 0023; 0024
4664-01-1
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$8.00/1g
7579-20-6
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179024-65-8
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$63.00/500mg
7579-20-6
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$10.00/1g
59290-82-3
97 suppliers
$57.29/250mg
7579-20-6
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$10.00/1g
490-11-9
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$6.00/5g
7579-20-6
273 suppliers
$10.00/1g