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ChemicalBook CAS DataBase List 3-AMINO-9-FLUORENONE
6276-05-7

3-AMINO-9-FLUORENONE synthesis

2synthesis methods
42135-22-8 Synthesis
3-nitrofluoren-9-one

42135-22-8
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Yield:6276-05-7 95%

Reaction Conditions:

with ethanol;ironReflux;

Steps:

1.1.2 2) Synthesis of 3-amino-9-fluorenone

3-Nitro-9-fluorenone (1.87 g) and ethanol in a weight ratio of 1:50 was added to the reactor, iron powder (465mg) was stirred, was heated to reflux, the reaction overnight, TLC, starting material has disappeared fluorene nitro compound.cool down,The solid was removed by filtration,The solution was evaporated to dryness.Ethyl acetate was added 100mL dissolve,100mL organic phases were washed three times with saturated brine,The combined organic phases,After the drying agent was filtered and evaporated to dryness.Recrystallized from ethyl acetate and petroleum ether to give a purity of greater than 97% of 3-amino-9-fluorenyl ketone as a pale yellow solid (1.54g, 95%).

References:

CN105348330,2016,A Location in patent:Paragraph 0050; 0051

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