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ChemicalBook CAS DataBase List Fluorene
86-73-7

Fluorene synthesis

12synthesis methods
-

Yield:86-73-7 99%

Reaction Conditions:

with [RhCl2(p-cymene)]2;potassium tert-butylate in isopropyl alcohol at 20 - 100; for 24 h;Inert atmosphere;

Steps:

6 Example 6

At room temperature,In a reaction tube equipped with a stirring magnet, 0.2 mmol of the compound represented by the formula (I-6)0.005 mmol catalyst Dichloro (p-cymene) ruthenium dimer ([RuCl2 (cymene)] 2),0.24 mmol potassium tert-butoxide,Then purged with nitrogen,Under nitrogen protection was added 1mL isopropanol,Stirring heated to 100 ,And reacted at this temperature for 24h.After the reaction,The reaction solution was cooled to room temperature,Filtration with a layer of silica gel funnel,Then, the solvent was distilled off under reduced pressure,The residue is purified by flash column chromatography (petroleum ether)Thus, the target dehalogenation product represented by the formula (III-6) was obtained.Calculated,Yield greater than 99%.

References:

CN106588687,2017,A Location in patent:Paragraph 0069; 0070; 0071; 0072; 0073; 0074

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