2-Biphenylcarboxaldehyde synthesis
- Product Name:2-Biphenylcarboxaldehyde
- CAS Number:1203-68-5
- Molecular formula:C13H10O
- Molecular Weight:182.22
26260-02-6
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98-80-6
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1203-68-5
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Yield:1203-68-5 94%
Reaction Conditions:
with potassium carbonate in ethanol;water at 20; for 1 h;Green chemistry;Suzuki-Miyaura Coupling;
Steps:
2.8 General Procedure for Suzuki-Miyaura Cross-Coupling Reaction
General procedure: A mixture of aryl halide (0.27 mmol), phenylboronicacid (1 mmol), NHC-PdGO heterogeneous catalyst(0.01g) and potassium carbonate (1.1mmol) was stirred inEtOH:H2O (1:1) solvent system at room temperature for designated hours. The progress of the reaction was monitoredby TLC. After reaction completion, the mixture was cooledto room temperature and NHC-PdGO heterogeneous catalystwas separated through centrifugation. To the filtrate,dichloromethane and water were added. Dichloromethanelayer was separated from the water layer using a separatoryfunnel and dried with magnesium sulphate. The drieddichloromethane was concentrated in vacuum and obtainedcrude product was purified from column chromatographyover silica gel using hexane and ethyl acetate as eluting solventto get the corresponding products in good to excellentyields. All the coupled products were known molecules andwere confirmed by comparing the 1H NMR spectral datawith those of authentic samples.
References:
Kandathil, Vishal;Kulkarni, Bhakti;Siddiqa, Aisha;Kempasiddaiah, Manjunatha;Sasidhar;Patil, Shivaputra A.;Patil, Siddappa A. [Catalysis Letters,2020,vol. 150,# 2,p. 384 - 403]
2928-43-0
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1203-68-5
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2996-92-1
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6630-33-7
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1203-68-5
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108-86-1
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40138-16-7
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1203-68-5
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$14.00/1g