3,5-Bis(trifluoromethyl)phenol synthesis
- Product Name:3,5-Bis(trifluoromethyl)phenol
- CAS Number:349-58-6
- Molecular formula:C8H4F6O
- Molecular Weight:230.11
328-73-4
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$9.00/1g
349-58-6
179 suppliers
$11.00/1g
Yield:349-58-6 96%
Reaction Conditions:
with water;ethylene glycol;potassium hydroxide;copper dichloride in dimethyl sulfoxide at 120; for 24 h;Inert atmosphere;
Steps:
General Procedure A.
General procedure: To a test tube containing a magnetic bar was added aryl halide (1.0 mmol), CuCl2 (13.4 mg, 0.1 mmol), KOH (336 mg, 6.0 mmol), ethylene glycol(12 μL, 0.2 mmol), and DMSO/H2O (1.0 mL/0.5 mL). After flushing with argon, the mixture was stirred in a preheated oil bath at 120 °C for 24 h. After cooled to ambient temperature, the reaction mixture was distributed in aqueous HCl (5 %) and ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous MgSO4, and concentrated under vacuum. The crude product was further purified by column chromatography (EtOAc/n-Hexane) to provide the phenols.
References:
Kim, Jihye;Battsengel, Oyunsaikhan;Liu, Yajun;Chae, Junghyun [Bulletin of the Korean Chemical Society,2015,vol. 36,# 12,p. 2833 - 2840] Location in patent:supporting information
328-70-1
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349-58-6
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$11.00/1g
73852-19-4
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$5.00/1g
349-58-6
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$11.00/1g
30071-93-3
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$10.00/10 g
349-58-6
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$11.00/1g
![2-[3,5-BIS(TRIFLUOROMETHYL)PHENOXY]ETHANOL](/StructureFile/ChemBookStructure7/GIF/CB4780863.gif)
887268-12-4
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$164.00/500mg
349-58-6
179 suppliers
$11.00/1g