ChemicalBook CAS DataBase List 3',5'-Bis(trifluoromethyl)acetophenone

3',5'-Bis(trifluoromethyl)acetophenone synthesis

8synthesis methods

Product Name:3',5'-Bis(trifluoromethyl)acetophenone
CAS Number:30071-93-3
Molecular formula:C10H6F6O
Molecular Weight:256.14

328-70-1
415 suppliers
$10.00/25 g

30071-93-3
373 suppliers
$10.00/10 g

Yield:30071-93-3 82%

Reaction Conditions:

with acetic anhydride;magnesium in tetrahydrofuran;water

Steps:

3 1-(3,5-Bis(trifluoromethyl)phenyl)ethan-1-one
EXAMPLE 3 1-(3,5-Bis(trifluoromethyl)phenyl)ethan-1-one A solution of 3,5-Bis(trifluoromethyl)bromobenzene (29.3 g) in 30 mL of THF was added to a mixture of magnesium granules (5.10 g) in THF (200 mL) heated at reflux (the reaction was initiated with approximately 5 mL of the bromide solution; the remainder was added slowly over 1 h). The mixture was aged for 30 min at reflux, cooled to RT and added over 1 h to a solution of acetic anhydride (40 mL) in THF (40 mL) maintained at -15° C. The resulting dark brown mixture was warmed to 10° C. in a water bath, and water (300 mL) was added. The pH of the vigorously stirred biphasic mixture was adjusted to 8.0 using 50% NaOH. MTBE (300 mL) was added, the layers were separated and the aqueous layer was further extracted with MTBE (3*150 mL). The organic layers were combined and concentrated in vacuo (bath at 30-35° C.; 50-80 torr). The concentrate was then distilled at atmospheric pressure to provide the pure product (20.7 g; 82% yield) with a boiling point of 187-189° C.

References:

McNamara, James M.;Zhao, Matthew M. US2002/22725, 2002, A1 Brands, Karel M. Jos;Tsay, Fuh-Rong;Conrad, Karen M.;Zhao, Matthew M. US2002/52494, 2002, A1

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401-96-7 Synthesis