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ChemicalBook CAS DataBase List 2-Piperidineethanol
1484-84-0

2-Piperidineethanol synthesis

1synthesis methods
2-Piperidineethanol is produced from 2-alpha-Pyridylethanol by hydrogenation.
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 30 percent / H2O2, sodium tungstate dihydrate / methanol / under 5 deg C, then Rt, 24 h
2: CH2Cl2 / 12 h / Heating
3: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h
4: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating

References:

Carruthers, William;Moses, Roger C. [Journal of the Chemical Society. Perkin transactions I,1988,p. 2251 - 2254]

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