天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2-PHENYLTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER
7113-02-2

2-PHENYLTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER synthesis

9synthesis methods
-

Yield:7113-02-2 77%

Reaction Conditions:

in tetrahydrofuran; for 18 h;Reflux;

Steps:

3A Methyl 2-phenylthiazole-4-carboxylate

A solution of benzothioamide (4.0g, 29.2 mmol) in THF (80 mL) was treated dropwise with methyl bromopyruvate (7.6g, 39 mmol) and heated at reflux for 18 hours. The reaction was then concentrated under vacuum, diluted with ethyl acetate, washed with water (lx), brine (lx) and dried over anhydrous magnesium sulfate. The residue obtained after concentration was purified by silica gel chromatography (4.5 x 1 1 cm, 20% AcOEt/ toluene), followed by a second purification with 20% AcOEt/hexane. The title material was obtained after concentration as a yellow oil (5.25, 77%). 1H NMR (CDCl3, 400 MHz): 8.14 (s, 1H) 8.00 (m, 2H) 7.46-7.42 (m, 3H) 4.43 (q, J=7.0 Hz, 2H) 1.42 (t, J=7.3 Hz, 3H).

References:

WO2013/163279,2013,A1 Location in patent:Paragraph 00144

2-PHENYLTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER Related Search: