ETHYL 2-(2,3-DICHLOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLATE synthesis
- Product Name:ETHYL 2-(2,3-DICHLOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLATE
- CAS Number:175276-86-5
- Molecular formula:C12H9Cl2NO2S
- Molecular Weight:302.18
175276-86-5
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Yield:-
Reaction Conditions:
Stage #1: 2-(2,3-dichloro-phenyl)-thiazole-4-carboxylic acid ethyl esterwith methanol;lithium hydroxide;water for 4 h;Heating / reflux;
Stage #2: with hydrogenchloride in water; pH=2;Product distribution / selectivity;
Steps:
B.1
Step 1. Ester Hydrolysis; To a solution of 2-(2,3-dichloro-phenyl)-thiazole-4-carboxylic acid ethyl ester (Maybridge plc, Tintagel, Cornwall, UK; 20 g, 66.2 mmol) in MeOH (100 mL) and water (100 mL) was added LiOH (1.7 g. 72.8 mmol). After stirring for 4 h at reflux temperature, MeOH was evaporated in vacuo. To the residue was added more water, and the solution was acidified to pH 2 with concentrated HCl (7 mL), and extracted with EtOAc. The combined extracts were evaporated to give product which was used without further purification.
References:
US2007/167622,2007,A1 Location in patent:Page/Page column 12