ChemicalBook CAS DataBase List 2'-HYDROXY-6'-METHOXYACETOPHENONE

2'-HYDROXY-6'-METHOXYACETOPHENONE synthesis

13synthesis methods

Product Name:2'-HYDROXY-6'-METHOXYACETOPHENONE
CAS Number:703-23-1
Molecular formula:C9H10O3
Molecular Weight:166.17

Preparation by reaction of methyl iodide on 2,6-dihydroxyacetophenone with potassium carbonate in boiling acetone (56%).

699-83-2 Synthesis

699-83-2
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77-78-1
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703-23-1
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$21.00/1g

Yield: 96%

Reaction Conditions:

Stage #1:2,6-dihydroxylacetophenone with potassium carbonate in acetone for 0.166667 h;
Stage #2:dimethyl sulfate in acetone for 6 h;Reflux;

Steps:

1
15.5 g of compound (1)And anhydrous K2C0315. 18 g were placed in 250 mL of dry acetone (80 mL)Of a round bottom flask,Magnetic stirring with constant pressure dropping funnel lOminDimethyl sulphate was added dropwise15. 12gRefluxed for 6 h.Cooled to room temperature,The pH was adjusted to 2 with hydrochloric acid, extracted with ethyl acetate,The organic layers were combined, washed with water,Saturated saline wash,Dried over anhydrous sodium sulfate,Concentrated, recrystallized from methanol yellow crystals 15. 93g,Yield 96%.

References:

Guangxi Teachers Education University;HUANG, CHUSHENG;CHEN, JICHANG;LIU, HONGXING;SUN, ZHUO CN103570661, 2016, B Location in patent:Paragraph 0017-0018

699-83-2 Synthesis

699-83-2
470 suppliers
$6.00/5g