ChemicalBook CAS DataBase List 2-aminobutyrophenone

2-aminobutyrophenone synthesis

8synthesis methods

Product Name:2-aminobutyrophenone
CAS Number:2034-40-4
Molecular formula:C10H13NO
Molecular Weight:163.22

577-59-3 Synthesis

577-59-3
273 suppliers
$6.00/5g

64-17-5 Synthesis

64-17-5
725 suppliers
$10.00/50g

491-35-0
248 suppliers
$10.00/10g

2034-40-4
15 suppliers
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551-93-9 Synthesis

551-93-9
480 suppliers
$6.00/5g

Yield:2034-40-4 6 %Chromat. ，551-93-9 67 %Chromat. ，491-35-0 27 %Chromat.

Reaction Conditions:

with sodium hydroxide at 120; for 24 h;

Steps:

Reduction and chain elongation

General procedure: A mixture of 4-nitroacetophenone (0.83 g,5 mmol), NaOH (0.6 g), Pd/MgLaO (0.2 g) and the appropriate alcohol (10 ml)were stirred at 120 C (bath temperature) for 24 h. The mixture was filtered,the solid was washed with MeOH and the filtrate was concentrated in vacuum.The residue was dissolved in Et2O and H2O. Dilute HCl (25%) was added untilpH 1. The two phases were separated and the aqueous phase basified to pH 8by adding NaHCO3. The aqueous phase was extracted with Et2O (2 50 mL).The organic phase was dried over Na2SO4 and concentrated in vacuum. Theproducts were purified by column chromatography

References:

Németh, János;Kiss, árpád;Hell, Zoltán [Tetrahedron Letters,2013,vol. 54,# 45,p. 6094 - 6096]