2-Amino-6-methyl-4-pyrimidinol synthesis
- Product Name:2-Amino-6-methyl-4-pyrimidinol
- CAS Number:3977-29-5
- Molecular formula:C5H7N3O
- Molecular Weight:125.13
Yield:3977-29-5 76%
Reaction Conditions:
with sodium carbonate in water at 60; for 0.5 h;Sonication;Reagent/catalyst;
Steps:
General procedure for the sonochemical synthesis of 2-aminopyrimidine derivatives
General procedure: Into the round-bottom reaction vessels having an appropriate thickness for the sonochemicalreactions; guanidine hydrochloride (0.052 mol) and corresponding β-diketone compound (0.052 mol) were placed in water (15 mL) and Na2CO3 (0.052 mol). The reaction vessel has been put in a hot water bath at 60°C, and the flask content was exposed to ultrasonic waves for 30 min. The solid product obtained at the end of the experiment was treated with a small quantity of water and filtered through the Nuche funnel.
References:
Bayramo?lu, Duygu;Kurtay, Gülbin;Güllü, Mustafa [Synthetic Communications,2020,vol. 50,# 5,p. 649 - 658]
