ChemicalBook CAS DataBase List Guanidine hydrochloride

Guanidine hydrochloride synthesis

6synthesis methods

Product Name:Guanidine hydrochloride
CAS Number:50-01-1
Molecular formula:CH5N3.ClH
Molecular Weight:95.53

The preparation of guanidine hydrochloride is as follows:Step 1, Fritting. Put dicyandiamide and ammonium chloride with a weight ratio of 1:1.27 into the reactor for frit reaction at 170~230℃, then we can obtain the crude guanidine hydrochloride.Step 2, Dissolving. At normal temperature, the crude guanidine hydrochloride is dissolved in water at a ratio of 1:1, and the solution is added with the ammonium salt alkaloid whose dosage is determined according to the content of the ammonium salt in the crude guanidine hydrochloride;Step 3, Filtering. Remove the raw materials and reaction by-products by filtration;Step 4, Dehydrating. Dehydrate the filtered ground mother liquor at high temperature;Step 5, Crystallizing. Cool the supersaturated solution, concentrate and crystallize to obtain high-purity guanidine hydrochloride.Step 6, Put dicyandiamide into reactor with the guanidine hydrochloride after step 5, and the frit reaction was carried out at 170~230℃ for 3~4h. Then, the higher purity guanidine hydrochloride was obtained through steps 2, 3, 4 and 5, and this step can be repeated several times as needed.Step 7, The guanidine hydrochloride after step 5 is then subjected to steps 2, 3, 4, and 5, wherein the ratio to water in step 2 is 1.5:1 to obtain higher purity guanidine hydrochloride, and this can be repeated numerous times as required.

1066-33-7 Synthesis