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ChemicalBook CAS DataBase List 2-(4-FLUOROBENZOYL)ACETIC ACID
7761-30-0

2-(4-FLUOROBENZOYL)ACETIC ACID synthesis

9synthesis methods
Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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Yield: 86%

Reaction Conditions:

with hydrogenchloride in waterReflux;

Steps:

118.2
[00389] Step 2: A suspension of (2)-4-(4-fluorobenzylidene)-2-methyloxazol-5(4H)- one (2.00 g, 9.75 mmol) in 3 N HC1 (60 mL) was heated to reflux. The reaction was allowed to cool to room temperature and then was cooled in an ice bath with stirring. The solid was isolated by filtration and rinsing with water followed by drying under high vacuum to provide 3-(4-fluorophenyl)-2-oxopropanoic acid (1.56 g, 86% yield) as a solid.

References:

ARRAY BIOPHARMA INC.;GENENTECH, INC.;BLAKE, James, F.;COOK, Adam;GAUDINO, John;GUNAWARDANA, Indrani, W.;HICKEN, Erik, James;HUNT, Kevin, W.;LYON, Michael;METCALF, Andrew, T.;MOHR, Peter, J.;MORENO, David, A.;NEWHOUSE, Brad;REN, Li;SCHWARZ, Jacob;CHEN, Huifen;GAZZARD, Lewis;SCHMIDT, Jane;DO, Steve WO2015/103137, 2015, A1 Location in patent:Paragraph 00389

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