1H-Indazole-3-acetic acid, Methyl ester synthesis
- Product Name:1H-Indazole-3-acetic acid, Methyl ester
- CAS Number:131666-74-5
- Molecular formula:C10H10N2O2
- Molecular Weight:190.2
67-56-1
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$9.00/25ml
26663-42-3
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$73.00/100mg
131666-74-5
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$63.00/100mg
Yield:131666-74-5 93%
Reaction Conditions:
with sulfuric acid at 68; for 16 h;
Steps:
Synthesis of (1H-Indazol-3-yl)-acetic acid methyl ester (35-2):
To a stirred solution of 2-(1H-indazol-3-yl)acetic acid (35-1) (4.86 g, 27.5 mmol) in Methanol (250 mL ) was added sulfuric acid (0.543 g, 5.53 mmol) and the reaction was refluxed at 68°C for 16 h. Reaction progress was monitored by TLC. The MeOH was evaporated to dryness and the residual gum was basified with saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulphate and evaporated in vacuo to yield methyl 2-(1H-indazol-3-yl)acetate (35-2) (4.90 g, 25.7 mmol, 93 %) as a light brown solid.
References:
WO2017/197046,2017,A1 Location in patent:Page/Page column 328
26663-42-3
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$73.00/100mg
131666-74-5
47 suppliers
$63.00/100mg
26663-42-3
89 suppliers
$73.00/100mg
18107-18-1
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$33.00/5g
131666-74-5
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$63.00/100mg
174180-42-8
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131666-74-5
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$63.00/100mg
101714-15-2
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131666-74-5
47 suppliers
$63.00/100mg