Methyl 2-chloro-3-quinolinecarboxylate synthesis
- Product Name:Methyl 2-chloro-3-quinolinecarboxylate
- CAS Number:16498-85-4
- Molecular formula:C11H8ClNO2
- Molecular Weight:221.64
67-56-1
752 suppliers
$7.29/5ml-f
73776-25-7
99 suppliers
$45.00/50mg
16498-85-4
50 suppliers
$25.00/100mg
Yield: 80%
Reaction Conditions:
with sulfuric acid at 60; for 2 h;
Steps:
434.a Example 434 step a:
A solution of the compound 2-chloroquinoline-3-carboxylic acid (414 mg, 2 mmol) in MeOH(20 mL) and H2S04 (1 mL) was stirred for 2 hours at 60 °C. It was quenched by H20 (30 mL)at 0 °C and adjusted pH to 89, extracted with EA (3x), dried Na2SO4, filtered to give desiredcompound as a yellow solid (354 mg, 80 %). ESI MS m/z = 222.2 [M+Hjt
References:
ENANTA PHARMACEUTICALS, INC.;SHOOK, Brian, C.;KIM, In, Jong;BLAISDELL, Thomas, P.;YU, Jianming;PANARESE, Joseph;OR, Yat, Sun WO2017/15449, 2017, A1 Location in patent:Page/Page column 325
67-56-1
752 suppliers
$7.29/5ml-f
73568-25-9
189 suppliers
$9.00/250mg
16498-85-4
50 suppliers
$25.00/100mg
62-53-3
658 suppliers
$10.00/1g
16498-85-4
50 suppliers
$25.00/100mg
103-84-4
346 suppliers
$12.00/100g
16498-85-4
50 suppliers
$25.00/100mg
91301-03-0
62 suppliers
$41.39/250mg
16498-85-4
50 suppliers
$25.00/100mg