(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate synthesis
- Product Name:(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
- CAS Number:174649-09-3
- Molecular formula:C15H19FN2O6S
- Molecular Weight:374.38
124-63-0
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Yield: 100%
Reaction Conditions:
with triethylamine in dichloromethane at 0; for 0.5 h;
Steps:
5
To a solution of 132.8 g of (R)-N-[[3-[3-fluoro-4-morpholinyl]phenyl]-2-oxo-5- oxazolidinyl] methanol and 87.1 g of triethylamine in IL of methylene dichloride at O0C under nitrogen was added 74 gm of methanesulfonyl chloride. The reaction mixture was allowed to stir at 0°C for 30 min, then allowed to warm to ambient temperature. A white solid was precipitated. 1.75 L water, 6.50 L methylene dichloride and IL ethyl acetate mixture were added followed by stirring for 30 min. The reaction mass was filtered to get a white solid. Yield: 140 g.; Percentage: 105.42% w/w
References:
USV LIMITED WO2009/63505, 2009, A2 Location in patent:Page/Page column 14
369-34-6
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174649-09-3
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93246-53-8
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174649-09-3
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-, phenylmethyl ester (9CI)](/CAS/20210111/GIF/912552-55-7.gif)
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174649-09-3
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