ChemicalBook CAS DataBase List 1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-, ETHYL ESTER

1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-, ETHYL ESTER synthesis

4synthesis methods

Product Name:1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-, ETHYL ESTER
CAS Number:162713-88-4
Molecular formula:C14H18O3
Molecular Weight:234.29

21779-34-0
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1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-, ETHYL ESTER

162713-88-4
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Yield:162713-88-4 99%

Reaction Conditions:

with hydrogen;palladium in ethanol;

Steps:

130 Preparation of Ethyl (5-methoxy-2,3-dihydro-1H-inden-1-yl)acetate

Example 130 Preparation of Ethyl (5-methoxy-2,3-dihydro-1H-inden-1-yl)acetate The crude product of Example 129 was dissolved in absolute ethanol (2.6 L) and hydrogenated at 40 psi of hydrogen over 10% palladium on carbon (21.6 g). Filtration through Celite and concentration of the filtrate afforded 433.3 g of brown oil (99% yield for 2 steps). ¹H NMR (CDCl₃): δ 7.1 (dd, 1H), 6.8 (d, 1H), 6.7 (dd, 1H), 4.2 (q, 2H), 3.8 (s, 3H), 3.5 (m, 1H), 2.9 (m, 2H), 2.7 (dd, 1H), 2.4 (m, 2H), 1.7 (m, 1H), 1.3 (t, 3H). MS (Cl) m/z 235 [M+H]⁺.

References:

US2003/216391,2003,A1