ChemicalBook CAS DataBase List 1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-

1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO- synthesis

12synthesis methods

Product Name:1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-
CAS Number:38425-65-9
Molecular formula:C11H12O2
Molecular Weight:176.21

22339-45-3 Synthesis

1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-, ETHYL ESTER

22339-45-3
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38425-65-9
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Yield:38425-65-9 900 mg

Reaction Conditions:

with water;sodium hydroxide in methanol at 40; for 2 h;

Steps:

171.C

C. To a solution of ethyl 2-(2,3-dihydro-1H-inden-1-yl)acetate (1.1 g, 5.39 mmol) in CH3OH (20 mL) was added sodium hydroxide (0.65 g, 16.17 mmol) and H2O (2 mL). The reaction mixture was heated to 40 °C and stirred at that temperature for 2 h then was concentrated in vacuo.1M aqueous HCl (30 mL) was added to the reaction vessel and the resulting biphasic mixture was extracted with DCM (3 x 50 mL). The organic phase was washed with saturated aqueous NaCl (2 x 25 mL). The combined organics were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to provide 2-(2,3-dihydro-1H-inden-1-yl)acetic acid (900 mg, 5.11 mmol) as a white solid.

References:

WO2018/26371,2018,A1 Location in patent:Paragraph 0127; 0303

25173-12-0 Synthesis