Methyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoate synthesis

9synthesis methods

Product Name:Methyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoate
CAS Number:1235865-76-5
Molecular formula:C34H37ClN4O3
Molecular Weight:585.14

1228780-72-0 Synthesis

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine

1228780-72-0
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Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate

1235865-75-4
192 suppliers
$66.00/1g

Methyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoate

1235865-76-5
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Yield: 76%

Reaction Conditions:

with dipotassium hydrogenphosphate in dimethyl sulfoxide at 140; for 12 h;Inert atmosphere;

Steps:

3.5 Step 5 Synthesis of Compound 21.
Under nitrogen protection, Compound 20 (1.0 g, 3.13 mmol), Compound 1 (0.9 g, 3.13 mmol) and dipotassium hydrogen phosphate (1.10 g, 6.26 mmol) Add to a solution of dimethyl sulfoxide (DMSO, 25 ml), The reaction solution was reacted at 140 ° C for 12 h, and cooled to room temperature. The reaction was quenched with water (50 mL). Dry over anhydrous sodium sulfate, remove the solvent,The concentrate is subjected to column separation (eluent: petroleum ether/ethyl acetate (v/v) = 3:1), Obtained 1.4 g of a yellow oil, The yield was 76%.

References:

Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.;Wang Yihan;Liu Zhiqiang CN108658983, 2018, A Location in patent:Paragraph 0153; 0156; 0165; 0166

32767-46-7 Synthesis