ChemicalBook CAS DataBase List 10-Hydroxybenzo[h]quinoline

10-Hydroxybenzo[h]quinoline synthesis

5synthesis methods

Product Name:10-Hydroxybenzo[h]quinoline
CAS Number:33155-90-7
Molecular formula:C13H9NO
Molecular Weight:195.22

152583-10-3 Synthesis

152583-10-3
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33155-90-7
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Yield:33155-90-7 95%

Reaction Conditions:

with ortho-methylbenzoic acid;potassium fluoride;silver carbonate in para-xylene at 150; for 24 h;Reagent/catalyst;Temperature;

Steps:

Experimental Procedures for the Hydroxylation
General procedure: 10-Bromobenzo[h]quinoline (0.15 mmol, 39 mg), carboxylic acid (0.3 mmol), silver carbonate (Ag based 0.165 mmol, 22mg), potassium fluoride (0.15 mmol, 9 mg), and p-xylene (0.5 mL) were added to an oven-dried screw-capped vial. The mixture was vigorously stirred at 150 ^oC for 24 h and then the resulting mixture was allowed to cool to room temperature and then diluted with ethyl acetate. Solvent was removed in vacuo, and the desired product was isolated by a silica gel column chromatography.

References:

Yoo, Kwangho;Park, Hyojin;Kim, Suyeon;Kim, Min [Tetrahedron Letters,2016,vol. 57,# 7,p. 781 - 783] Location in patent:supporting information

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230-27-3 Synthesis