1-(CHLOROACETYL)-4-(2-CHLOROPHENYL)PIPERAZINE synthesis
1synthesis methods
- Product Name:1-(CHLOROACETYL)-4-(2-CHLOROPHENYL)PIPERAZINE
- CAS Number:330601-49-5
- Molecular formula:C12H14Cl2N2O
- Molecular Weight:273.16
Yield:-
Reaction Conditions:
with triethylamine in dichloromethane; for 5 h;
Steps:
General procedure: To a solution of a substitued phenylpiperazines (6.0mmol) in CH2Cl2 (30 mL) containing triethylamine (1 mL), chloroacetyl chloride (0.48 mL, 6.0 mmol) was addeddropwise with stirring in ice water bath. Stirring was continuedfor 5 h and the reaction mixture was washed with10% NaOH solution (2 × 5 mL). The organic layer was collected.After drying with anhydrous Na2SO4, the solventwas removed in vacuo to yield the intermediate 5a-f.
References:
Liu, Zhi-Ping;Gong, Chang-Da;Xie, Long-Yan;Du, Xiu-Li;Li, Yang;Qin, Jie [Acta Chimica Slovenica,2019,vol. 66,# 2,p. 421 - 426]