WZ8040
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- $120 - $10100
- Product name: WZ8040
- CAS: 1214265-57-2
- MF: C24H25ClN6OS
- MW: 481.01
- EINECS:-0
- MDL Number:MFCD18074511
- Synonyms:WZ8040;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide;N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide WZ8040;N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)thio)phenyl)acrylami;CS-471;WZ-8040;WZ 8040;2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-
20 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- DC Chemicals
Package
- 10mM(in 1mL DMSO)
- 5mg
- 10mg
- 25mg
- 50MG
- 100mg
- 250mg
- 1G
- ManufacturerAK Scientific
- Product numberX7483
- Product descriptionN-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide
- Packaging5mg
- Price$268
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7483
- Product descriptionN-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide
- Packaging10mg
- Price$421
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7483
- Product descriptionN-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide
- Packaging25mg
- Price$816
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000899
- Product descriptionWZ-8040 95.00%
- Packaging5MG
- Price$510
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000899
- Product descriptionWZ-8040 95.00%
- Packaging10MG
- Price$565
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000899
- Product descriptionWZ-8040 95.00%
- Packaging50MG
- Price$885
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000899
- Product descriptionWZ-8040 95.00%
- Packaging1G
- Price$10100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1393
- Product descriptionWZ8040
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1393
- Product descriptionWZ8040
- Packaging10mM(in 1mL DMSO)
- Price$230
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1393
- Product descriptionWZ8040
- Packaging25mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1393
- Product descriptionWZ8040
- Packaging100mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611642
- Product descriptionWZ8040
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611642
- Product descriptionWZ8040
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611642
- Product descriptionWZ8040
- Packaging1g
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number30062
- Product descriptionWZ8040
- Packaging5mg
- Price$153
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number30062
- Product descriptionWZ8040
- Packaging10mg
- Price$290
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7483 | N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide | 5mg | $268 | 2021-12-16 | Buy |
| AK Scientific | X7483 | N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide | 10mg | $421 | 2021-12-16 | Buy |
| AK Scientific | X7483 | N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide | 25mg | $816 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000899 | WZ-8040 95.00% | 5MG | $510 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000899 | WZ-8040 95.00% | 10MG | $565 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000899 | WZ-8040 95.00% | 50MG | $885 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000899 | WZ-8040 95.00% | 1G | $10100 | 2021-12-16 | Buy |
| ApexBio Technology | A1393 | WZ8040 | 5mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A1393 | WZ8040 | 10mM(in 1mL DMSO) | $230 | 2021-12-16 | Buy |
| ApexBio Technology | A1393 | WZ8040 | 25mg | $360 | 2021-12-16 | Buy |
| ApexBio Technology | A1393 | WZ8040 | 100mg | $800 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611642 | WZ8040 | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611642 | WZ8040 | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611642 | WZ8040 | 1g | $1802 | 2021-12-16 | Buy |
| Cayman Chemical | 30062 | WZ8040 | 5mg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 30062 | WZ8040 | 10mg | $290 | 2024-03-01 | Buy |
Properties
Density :1.37
storage temp. :Store at -20°C
solubility :≥24.05 mg/mL in DMSO; insoluble in H2O; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :12.94±0.70(Predicted)
color :Light yellow to green yellow
storage temp. :Store at -20°C
solubility :≥24.05 mg/mL in DMSO; insoluble in H2O; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :12.94±0.70(Predicted)
color :Light yellow to green yellow
Safety Information
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Description
WZ8040 is an inhibitor of mutant EGF receptors (EGFRs) with IC50 values ranging from 2 to 306 nM in Ba/F3 cells. It is selective for EGFR mutants, including the EGFRDel E746_A750 and EGFRL858R mutations conferring gefitinib sensitivity and the EGFRDel E746_A750/T790M mutation conferring gefitinib resistance (IC50s = 2, 6, and 6 nM in Ba/F3 cells), over wild-type EGFR (IC50 = 1,820 nM in HN11 cells) but also inhibits ERBB2Ins G776V,C and wild-type ERBB2 (IC50s = 20 and 32 nM, respectively, in Ba/F3 cells). WZ8040 inhibits proliferation of PC-9 cells harboring the EGFRDel E746_A750 mutation and gefitinib-resistant PC-9 GR cells harboring the EGFRT790M resistant allele (EC50s = 6 and 8 nM, respectively).More related product prices
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