WZ8040
Catalog No.
A1393
EGFR T790M inhibitor,irreversible amd potent
Featured Products
WZ8040 is a novel, irreversible mutant-selective EGFR kinase inhibitor that specifically inhibits phosphorylation of EGFRT790M.
WZ8040 shows to suppress the growth of?EGFR?T790M containing cell lines as well as inhibit phosphorylation of EGFR in the Non–Small-Cell Lung Cancer (NSCLC) cells. WZ8040 was identified from the screen that possessed up to a 300-fold lower IC50?against the PC9GR cells compared to clinical stage inhibitors such as HKI-272 [1].
References:
[1] Zhou W1,?Ercan D,?Chen L,?Yun CH,?Li D,?Capelletti M,?Cortot AB,?Chirieac L,?Iacob RE,?Padera R,?Engen JR,?Wong KK,?Eck MJ,?Gray NS,?J?nne PA. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature.?2009 Dec 24;462(7276):1070-4. doi: 10.1038/nature08622.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 481.01 |
| Cas No. | 1214265-57-2 |
| Formula | C24H25ClN6OS |
| Solubility | ≥24.05 mg/mL in DMSO; insoluble in H2O; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide |
| SDF | Download SDF |
| Canonical SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | WZ8040 is an irreversible inhibitor of EGFR T790M with IC50 value of <10nM. | |||||
| Targets | EGFR T790M | |||||
| IC50 | <10nM | |||||
Quality Control & MSDS
- View current batch:
Chemical structure
