Trilostane
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- $39 - $1593.9
- Product name: Trilostane
- CAS: 13647-35-3
- MF: C20H27NO3
- MW: 329.43
- EINECS:237-133-0
- MDL Number:MFCD00199295
- Synonyms:TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car ;17-beta)-ph ;(4a,5a,17b)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile;5a-Androstane-2a-carbonitrile, 4a,5-epoxy-17b-hydroxy-3-oxo-;Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4a,5a,17b)-;4α,5-Epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile;4α,5-Epoxy-3,17β-dihydroxy-5α-androstan-2-ene-2-carbonitrile
26 prices
Selected condition：
Brand
- AHH
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 5mg
- 10mg
- 50mg
- 100MG
- 1g
- 5G
- 10g
- 25g
- 50g
- 500g
- 10mM(in 1mL DMSO)
- 250g
- ManufacturerAHH
- Product numberMT-59927
- Product descriptionTrilostane 99%
- Packaging1g
- Price$630
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ40158
- Product descriptionTrilostane
- Packaging50mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ11209
- Product descriptionTrilostane
- Packaging10mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0004508
- Product descriptionTRILOSTANE 95.00%
- Packaging10MG
- Price$704.55
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0004508
- Product descriptionTRILOSTANE 95.00%
- Packaging100MG
- Price$1593.9
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4348
- Product descriptionTrilostane
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3089
- Product descriptionTrilostane
- Packaging10mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3089
- Product descriptionTrilostane
- Packaging100mg
- Price$69
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3089
- Product descriptionTrilostane
- Packaging1g
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon3317
- Product descriptionTrilostane-WIN24540 99%
- Packaging50mg
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT28510
- Product descriptionTrilostane
- Packaging50g
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT28510
- Product descriptionTrilostane
- Packaging1g
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT28510
- Product descriptionTrilostane
- Packaging25g
- Price$325
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT28510
- Product descriptionTrilostane
- Packaging500g
- Price$275
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT28510
- Product descriptionTrilostane
- Packaging250g
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT28510
- Product descriptionTrilostane
- Packaging10g
- Price$165
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AHH | MT-59927 | Trilostane 99% | 1g | $630 | 2021-12-16 | Buy |
| AK Scientific | J40158 | Trilostane | 50mg | $95 | 2021-12-16 | Buy |
| AK Scientific | J11209 | Trilostane | 10mg | $49 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004508 | TRILOSTANE 95.00% | 10MG | $704.55 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004508 | TRILOSTANE 95.00% | 100MG | $1593.9 | 2021-12-16 | Buy |
| ApexBio Technology | A4348 | Trilostane | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| AvaChem | 3089 | Trilostane | 10mg | $39 | 2021-12-16 | Buy |
| AvaChem | 3089 | Trilostane | 100mg | $69 | 2021-12-16 | Buy |
| AvaChem | 3089 | Trilostane | 1g | $189 | 2021-12-16 | Buy |
| Axon Medchem | Axon3317 | Trilostane-WIN24540 99% | 50mg | $99 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT28510 | Trilostane | 50g | $500 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT28510 | Trilostane | 1g | $400 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT28510 | Trilostane | 25g | $325 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT28510 | Trilostane | 500g | $275 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT28510 | Trilostane | 250g | $175 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT28510 | Trilostane | 10g | $165 | 2021-12-16 | Buy |
Properties
Melting point :264 °C
alpha :D25 +137.4° (c = 1 in pyridine)
Boiling point :467.02°C (rough estimate)
Density :1.1213 (rough estimate)
refractive index :1.5614 (estimate)
storage temp. :2-8°C
solubility :DMSO: ≥17mg/mL
form :powder
pka :8.57±0.70(Predicted)
color :white to tan
InChIKey :KVJXBPDAXMEYOA-CXANFOAXSA-N
SMILES :[C@@]123CC[C@@]4([H])[C@]5([H])CC[C@H](O)[C@@]5(C)CC[C@]4([H])[C@@]1(C)CC(C#N)=C(O)[C@@]2([H])O3 |&1:0,3,5,9,11,15,17,25,r|
CAS DataBase Reference :13647-35-3(CAS DataBase Reference)
EPA Substance Registry System :Trilostane (13647-35-3)
alpha :D25 +137.4° (c = 1 in pyridine)
Boiling point :467.02°C (rough estimate)
Density :1.1213 (rough estimate)
refractive index :1.5614 (estimate)
storage temp. :2-8°C
solubility :DMSO: ≥17mg/mL
form :powder
pka :8.57±0.70(Predicted)
color :white to tan
InChIKey :KVJXBPDAXMEYOA-CXANFOAXSA-N
SMILES :[C@@]123CC[C@@]4([H])[C@]5([H])CC[C@H](O)[C@@]5(C)CC[C@]4([H])[C@@]1(C)CC(C#N)=C(O)[C@@]2([H])O3 |&1:0,3,5,9,11,15,17,25,r|
CAS DataBase Reference :13647-35-3(CAS DataBase Reference)
EPA Substance Registry System :Trilostane (13647-35-3)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
3β-hydroxysteroid dehydrogenase (3β-HSD) type 1 and type 2 isoforms are key enzymes for the biosynthesis of all active steroid hormones. 3β-HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3β-HSD2 (type 2) is expressed in the adrenal gland, ovary, and testis. Trilostane is an inhibitor of the 3β-HSDs: 3β-HSD1 and 3β-HSD2 with Ki values of 0.10 and 1.60 μM, respectively. Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels. Because human 3β-HSD (type 1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, trilostane is also of interest for the treatment of breast cancer in postmenopausal women.Related product price
- Isobutylnitrite
$24-4131.67 - Isoamyl nitrite
$10-2349.27 - tert-Butyl nitrite
$29-4428.15
Suppliers and manufacturers
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd
