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ChemicalBook >> CAS DataBase List >> Torin 1

Torin 1

Torin 1 price.
  • $28 - $4500
  • Product name: Torin 1
  • CAS: 1222998-36-8
  • MF: C35H28F3N5O2
  • MW: 607.62
  • EINECS:
  • MDL Number:MFCD18782653
  • Synonyms:1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one;1-[4-(4-PROPANOYLPIPERAZIN-1-YL)-3-(TRIFLUOROMETHYL)PHENYL]-9-QUINOLIN-3-YLBENZO[H][1,6]NAPHTHYRIDIN-2-ONE;Torin 1;Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-;1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one Torin 1;Torin 1 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one;1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one;Torin 1, >=98%
35 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 1unit
  • 50
  • 5mg
  • 10
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberY0294
  • Product descriptionTorin1
  • Packaging10mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY0294
  • Product descriptionTorin1
  • Packaging50mg
  • Price$640
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8312
  • Product descriptionTorin1
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8312
  • Product descriptionTorin1
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8312
  • Product descriptionTorin1
  • Packaging25mg
  • Price$270
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60098
  • Product descriptionTorin1 ≥98%
  • Packaging10mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1833
  • Product descriptionTorin1 98%
  • Packaging5mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546140
  • Product descriptionTorin 1 >98%
  • Packaging5mg
  • Price$190.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546140
  • Product descriptionTorin 1 >98%
  • Packaging25mg
  • Price$521.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146133
  • Product descriptionTorin1 >98%
  • Packaging100mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146133
  • Product descriptionTorin1 >98%
  • Packaging250mg
  • Price$1356.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146133
  • Product descriptionTorin1 >98%
  • Packaging1g
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT103463
  • Product descriptionTorin 1
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT103463
  • Product descriptionTorin 1
  • Packaging50mg
  • Price$437.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10997
  • Product descriptionTorin 1 ≥95%
  • Packaging10mg
  • Price$146
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10997
  • Product descriptionTorin 1 ≥95%
  • Packaging25mg
  • Price$330
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y0294 Torin1 10mg $218 2021-12-16 Buy
AK Scientific Y0294 Torin1 50mg $640 2021-12-16 Buy
ApexBio Technology A8312 Torin1 1unit $28 2021-12-16 Buy
ApexBio Technology A8312 Torin1 5mg $70 2021-12-16 Buy
ApexBio Technology A8312 Torin1 25mg $270 2021-12-16 Buy
Arctom CFN60098 Torin1 ≥98% 10mg $218 2021-12-16 Buy
Axon Medchem Axon1833 Torin1 98% 5mg $99 2021-12-16 Buy
Biorbyt Ltd orb546140 Torin 1 >98% 5mg $190.4 2021-12-16 Buy
Biorbyt Ltd orb546140 Torin 1 >98% 25mg $521.9 2021-12-16 Buy
Biorbyt Ltd orb146133 Torin1 >98% 100mg $765 2021-12-16 Buy
Biorbyt Ltd orb146133 Torin1 >98% 250mg $1356.6 2021-12-16 Buy
Biorbyt Ltd orb146133 Torin1 >98% 1g $2691.1 2021-12-16 Buy
Biosynth Carbosynth FT103463 Torin 1 10mg $125 2021-12-16 Buy
Biosynth Carbosynth FT103463 Torin 1 50mg $437.5 2021-12-16 Buy
Cayman Chemical 10997 Torin 1 ≥95% 10mg $146 2024-03-01 Buy
Cayman Chemical 10997 Torin 1 ≥95% 25mg $330 2024-03-01 Buy

Properties

Melting point :>223°C (dec.)
Boiling point :817.2±65.0 °C(Predicted)
Density :1.362
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 8 mg/ml).
form :Yellowish-white powder
pka :4.19±0.20(Predicted)
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.

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