Avagacestat (BMS-708163)
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- $44 - $3402
- Product name: Avagacestat (BMS-708163)
- CAS: 1146699-66-2
- MF: C20H17ClF4N4O4S
- MW: 520.89
- EINECS:
- MDL Number:MFCD13195458
- Synonyms:(2R)-2-[N-[(4-Chlorophenyl)sulfonyl]-N-[2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl]amino]-5,5,5-trifluoropentanamide;BMS-708163;(R)-2-(4-chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)phenylsulfonamido)-5,5,5-trifluoropentanamide;BMS-708163 (Avagacestat);Avagacestat;Avagacestat (BMS-708163);(R)-2-(4-Chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-phenylsulfonamido)-5,5,5-trifluoropen;(2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide
28 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
- Usbiological
Package
- 2mg
- 5
- 1MG
- 25
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX7561
- Product descriptionAvagacestat
- Packaging10mg
- Price$371
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7561
- Product descriptionAvagacestat
- Packaging50mg
- Price$1026
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0006208
- Product descriptionBMS-708163 95.00%
- Packaging1MG
- Price$148.05
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4022
- Product descriptionBMS-708163(Avagacestat)
- Packaging2mg
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4022
- Product descriptionBMS-708163(Avagacestat)
- Packaging5mg
- Price$103
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4022
- Product descriptionBMS-708163(Avagacestat)
- Packaging10mg
- Price$177
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4022
- Product descriptionBMS-708163(Avagacestat)
- Packaging50mg
- Price$536
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60263
- Product descriptionAvagacestat(BMS-708163) ≥98%
- Packaging5mg
- Price$258
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180781
- Product descriptionAvagacestat (BMS-708163) >98%
- Packaging100mg
- Price$986
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180781
- Product descriptionAvagacestat (BMS-708163) >98%
- Packaging250mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180781
- Product descriptionAvagacestat (BMS-708163) >98%
- Packaging1g
- Price$3282.7
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA43361
- Product descriptionBMS 708163
- Packaging10mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA43361
- Product descriptionBMS 708163
- Packaging50mg
- Price$647.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16711
- Product descriptionAvagacestat ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16711
- Product descriptionAvagacestat ≥98%
- Packaging5mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16711
- Product descriptionAvagacestat ≥98%
- Packaging10mg
- Price$341
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7561 | Avagacestat | 10mg | $371 | 2021-12-16 | Buy |
| AK Scientific | X7561 | Avagacestat | 50mg | $1026 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0006208 | BMS-708163 95.00% | 1MG | $148.05 | 2021-12-16 | Buy |
| ApexBio Technology | A4022 | BMS-708163(Avagacestat) | 2mg | $66 | 2021-12-16 | Buy |
| ApexBio Technology | A4022 | BMS-708163(Avagacestat) | 5mg | $103 | 2021-12-16 | Buy |
| ApexBio Technology | A4022 | BMS-708163(Avagacestat) | 10mg | $177 | 2021-12-16 | Buy |
| ApexBio Technology | A4022 | BMS-708163(Avagacestat) | 50mg | $536 | 2021-12-16 | Buy |
| Arctom | CFN60263 | Avagacestat(BMS-708163) ≥98% | 5mg | $258 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180781 | Avagacestat (BMS-708163) >98% | 100mg | $986 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180781 | Avagacestat (BMS-708163) >98% | 250mg | $1802 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180781 | Avagacestat (BMS-708163) >98% | 1g | $3282.7 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA43361 | BMS 708163 | 10mg | $185 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA43361 | BMS 708163 | 50mg | $647.5 | 2021-12-16 | Buy |
| Cayman Chemical | 16711 | Avagacestat ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16711 | Avagacestat ≥98% | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 16711 | Avagacestat ≥98% | 10mg | $341 | 2024-03-01 | Buy |
Properties
Density :1.488
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥177.6 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form :Powder
color :White to off-white
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥177.6 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form :Powder
color :White to off-white
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||
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Description
γ-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and β-amyloid precursor protein (APP), within the transmembrane domain. Avagacestat is a potent, orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP to Aβ40 than signaling through Notch (IC50s = 0.30 and 58 nM, respectively). It shows good pharmacokinetics in rats, dogs, and humans and passes the blood-brain barrier, reducing plasma, brain, and cerebrospinal fluid Aβ40 levels. While suppressing the production of Aβ38, Aβ40, and Aβ42, γ-secretase inhibitors, including avagacestat, increase the level of APP β-C-terminal fragment, both in vitro and in vivo, altering cell function. Avagacestat may impact Notch signaling in vivo, although it is generally considered a “Notch-sparing” γ-secretase inhibitor.More related product prices
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