GDC-0152
|
- $44 - $550
- Product name: GDC-0152
- CAS: 873652-48-3
- MF: C25H34N6O3S
- MW: 498.64
- EINECS:
- MDL Number:MFCD26142660
- Synonyms:GDC-0152;(S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide;L-Prolinamide, N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-;GDC0152;GDC 0152.;CS-2247;GDC-0152; GDC0152; GDC 0152.;GDC-0152 USP/EP/BP;GDC-0152,IAP,Inhibitor,inhibit,GDC 0152
11 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 50mg
- 100mg
- 10mM(in 1mL DMSO)
- 5MG
- 10mg
- 25mg
- ManufacturerAK Scientific
- Product number2426AH
- Product descriptionGDC-0152
- Packaging10mg
- Price$290
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2426AH
- Product descriptionGDC-0152
- Packaging25mg
- Price$528
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004770
- Product descriptionN-METHYL-L-ALANYL-(2S)-2-CYCLOHEXYLGLYCYL-N-(4-PHENYL-1,2,3-THIADIAZOL-5-YL)-L-PROLINAMIDE 95.00%
- Packaging5MG
- Price$497.29
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4224
- Product descriptionGDC-0152
- Packaging10mM(in 1mL DMSO)
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60385
- Product descriptionGDC-0152 ≥98%
- Packaging10mg
- Price$358
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17810
- Product descriptionGDC-0152 ≥95%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17810
- Product descriptionGDC-0152 ≥95%
- Packaging5mg
- Price$183
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17810
- Product descriptionGDC-0152 ≥95%
- Packaging10mg
- Price$299
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31000466
- Product descriptionGDC-0152 98+%
- Packaging50mg
- Price$437
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8597
- Product descriptionGDC-0152 >98%
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberG299920
- Product descriptionGDC0152
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2426AH | GDC-0152 | 10mg | $290 | 2021-12-16 | Buy |
| AK Scientific | 2426AH | GDC-0152 | 25mg | $528 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004770 | N-METHYL-L-ALANYL-(2S)-2-CYCLOHEXYLGLYCYL-N-(4-PHENYL-1,2,3-THIADIAZOL-5-YL)-L-PROLINAMIDE 95.00% | 5MG | $497.29 | 2021-12-16 | Buy |
| ApexBio Technology | A4224 | GDC-0152 | 10mM(in 1mL DMSO) | $140 | 2021-12-16 | Buy |
| Arctom | CFN60385 | GDC-0152 ≥98% | 10mg | $358 | 2021-12-16 | Buy |
| Cayman Chemical | 17810 | GDC-0152 ≥95% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17810 | GDC-0152 ≥95% | 5mg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 17810 | GDC-0152 ≥95% | 10mg | $299 | 2024-03-01 | Buy |
| Crysdot | CD31000466 | GDC-0152 98+% | 50mg | $437 | 2021-12-16 | Buy |
| DC Chemicals | DC8597 | GDC-0152 >98% | 100mg | $550 | 2021-12-16 | Buy |
| TRC | G299920 | GDC0152 | 5mg | $150 | 2021-12-16 | Buy |
Properties
Melting point :175-177oC
storage temp. :-20°C Freezer
solubility :DMSO (Slightly)
form :Solid
color :White
storage temp. :-20°C Freezer
solubility :DMSO (Slightly)
form :Solid
color :White
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Inhibitor of apoptosis proteins (IAPs), which block various signaling pathways leading to apoptotic cell death, are commonly over-expressed in cancer cells. GDC-0152 is a potent inhibitor of specific IAPs that binds baculoviral IAP repeat (BIR) domains (Kis = 28, 14, 17, and 43 nM for XIAP BIR3, NL-IAP BIR, BIRC2 (c-IAP1) BIR3, and BIRC3 (c-IAP2) BIR3, respectively). GDC-0152 induces activation of caspases, decreasing the viability of cancer cells without affecting normal cells. It is orally bioavailable and suppresses tumor growth in breast cancer xenografts in mice. GDC-0152 also induces NF-κB transcriptional activity, resulting in the expression of several cytokines, including TNF-α. In dogs and rats, but not humans, this leads to a pronounced inflammatory response.More related product prices
Birinapant 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide 779353-01-4 MK-2206 2HCl 936091-14-4 Ceritinib (LDK378)Related product price
- Birinapant
$57-4023.9 - 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-
carboxamide
$28-4644 - 779353-01-4
$28-3728.1