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ChemicalBook >> CAS DataBase List >> N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide

N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide

N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide price.
  • $44 - $4042.5
  • Product name: N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide
  • CAS: 936091-14-4
  • MF: C26H35N7O2S
  • MW: 509.67
  • EINECS:
  • MDL Number:MFCD15528085
  • Synonyms:TG101209, >=99%;N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide;TG101209/TG-101209;N-tert-Butyl-3-[[5-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]benzenesul;TG101209;TG 101209;TG-101209;CS-94;Benzenesulfonamide, N-(1,1-dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-;Cluster of differentiation antigen 135,RET,TG101209,Inhibitor,Janus kinase,CD135,Fms like tyrosine kinase 3,TG 101209,FLT3,TG-101209,Apoptosis,JAK,inhibit,Autophagy
26 prices
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  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1MG
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 1G
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1103-M005
  • Product descriptionTG101209 ≥95%
  • Packaging5mg
  • Price$194
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1103-M100
  • Product descriptionTG101209 ≥95%
  • Packaging100mg
  • Price$1723
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7457
  • Product descriptionN-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide
  • Packaging50mg
  • Price$451
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008253
  • Product descriptionTG-101209 95.00%
  • Packaging1MG
  • Price$246.75
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008253
  • Product descriptionTG-101209 95.00%
  • Packaging50MG
  • Price$1039.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008253
  • Product descriptionTG-101209 95.00%
  • Packaging100MG
  • Price$1443.75
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008253
  • Product descriptionTG-101209 95.00%
  • Packaging1G
  • Price$4042.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4145
  • Product descriptionTG101209
  • Packaging200mg
  • Price$1250
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB43338
  • Product descriptionN-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide
  • Packaging1mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB43338
  • Product descriptionN-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide
  • Packaging2mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB43338
  • Product descriptionN-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide
  • Packaging5mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB43338
  • Product descriptionN-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide
  • Packaging10mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB43338
  • Product descriptionN-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide
  • Packaging25mg
  • Price$560
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14696
  • Product descriptionTG101209 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14696
  • Product descriptionTG101209 ≥98%
  • Packaging5mg
  • Price$161
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14696
  • Product descriptionTG101209 ≥98%
  • Packaging10mg
  • Price$278
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1103-M005 TG101209 ≥95% 5mg $194 2021-12-16 Buy
Adipogen Life Sciences SYN-1103-M100 TG101209 ≥95% 100mg $1723 2021-12-16 Buy
AK Scientific X7457 N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide 50mg $451 2021-12-16 Buy
American Custom Chemicals Corporation API0008253 TG-101209 95.00% 1MG $246.75 2021-12-16 Buy
American Custom Chemicals Corporation API0008253 TG-101209 95.00% 50MG $1039.5 2021-12-16 Buy
American Custom Chemicals Corporation API0008253 TG-101209 95.00% 100MG $1443.75 2021-12-16 Buy
American Custom Chemicals Corporation API0008253 TG-101209 95.00% 1G $4042.5 2021-12-16 Buy
ApexBio Technology A4145 TG101209 200mg $1250 2021-12-16 Buy
Biosynth Carbosynth FB43338 N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide 1mg $110 2021-12-16 Buy
Biosynth Carbosynth FB43338 N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide 2mg $140 2021-12-16 Buy
Biosynth Carbosynth FB43338 N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide 5mg $175 2021-12-16 Buy
Biosynth Carbosynth FB43338 N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide 10mg $280 2021-12-16 Buy
Biosynth Carbosynth FB43338 N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide 25mg $560 2021-12-16 Buy
Cayman Chemical 14696 TG101209 ≥98% 1mg $44 2024-03-01 Buy
Cayman Chemical 14696 TG101209 ≥98% 5mg $161 2024-03-01 Buy
Cayman Chemical 14696 TG101209 ≥98% 10mg $278 2024-03-01 Buy

Properties

Melting point :243 °C
Boiling point :703.1±70.0 °C(Predicted)
Density :1.250
storage temp. :Store at -20°C
solubility :≥25.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :11.95±0.50(Predicted)
color :White to gray

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

TG101209 is a potent inhibitor of the tyrosine kinases janus kinase (JAK) 2, FMS-like tyrosine kinase 3, proto-oncogene RET, and JAK3 (IC50 = 6, 25, 17, and 169 nM, respectively). Through these effects, it induces cell cycle arrest and apoptosis in leukemic cell lines and CD45+ myeloma cells.

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