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ChemicalBook >> CAS DataBase List >> Esomeprazole

Esomeprazole

Esomeprazole price.
  • $17 - $1208.7
  • Product name: Esomeprazole
  • CAS: 119141-88-7
  • MF: C17H19N3O3S
  • MW: 345.42
  • EINECS:643-098-6
  • MDL Number:MFCD09907604
  • Synonyms:EsoMeprazole EC Pellets 22%;EsoMaprozole;1H-BenziMidazole,6-Methoxy-2-[(S)-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfinyl]-;EsoMeprazole EC Pellets 8.5%;6-Methoxy-2-{(S)-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfinyl}-1H-benziMidazole;Esomeprazole(Na、Mg);(5-methoxy-1H-benzimidazol-2-yl)[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfoniumolate;(S)-Esomeprazole
23 prices
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  • Ambeed
  • American Custom Chemicals Corporation
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Chemenu
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
Package
  • 1mg
  • 5MG
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 10g
  • 25g
  • 100g
  • ManufacturerAmbeed
  • Product numberA388173
  • Product description(S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99%
  • Packaging50mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA388173
  • Product description(S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99%
  • Packaging100mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA388173
  • Product description(S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99%
  • Packaging250mg
  • Price$76
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA388173
  • Product description(S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99%
  • Packaging1g
  • Price$187
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0019511
  • Product description(S)-6-METHOXY-2-(((4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL)SULFINYL)-1H-BENZO[D]IMIDAZOLE 95.00%
  • Packaging5MG
  • Price$501.55
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS542072
  • Product description(S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99%
  • Packaging1mg
  • Price$17
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS542072
  • Product description(S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99%
  • Packaging5mg
  • Price$34
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS542072
  • Product description(S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99%
  • Packaging100mg
  • Price$215
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS542072
  • Product description(S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99%
  • Packaging250mg
  • Price$312
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2660A
  • Product descriptionEsomeprazole
  • Packaging100mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2660A
  • Product descriptionEsomeprazole
  • Packaging1g
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2660A
  • Product descriptionEsomeprazole
  • Packaging10g
  • Price$390
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134728
  • Product descriptionEsomeprazole >99%
  • Packaging100mg
  • Price$414.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134728
  • Product descriptionEsomeprazole >99%
  • Packaging250mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134728
  • Product descriptionEsomeprazole >99%
  • Packaging1g
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM160492
  • Product description(S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 97%
  • Packaging25g
  • Price$262
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A388173 (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99% 50mg $39 2021-12-16 Buy
Ambeed A388173 (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99% 100mg $50 2021-12-16 Buy
Ambeed A388173 (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99% 250mg $76 2021-12-16 Buy
Ambeed A388173 (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99% 1g $187 2021-12-16 Buy
American Custom Chemicals Corporation API0019511 (S)-6-METHOXY-2-(((4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL)SULFINYL)-1H-BENZO[D]IMIDAZOLE 95.00% 5MG $501.55 2021-12-16 Buy
Arctom AS542072 (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99% 1mg $17 2021-12-16 Buy
Arctom AS542072 (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99% 5mg $34 2021-12-16 Buy
Arctom AS542072 (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99% 100mg $215 2021-12-16 Buy
Arctom AS542072 (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 99% 250mg $312 2021-12-16 Buy
AvaChem 2660A Esomeprazole 100mg $59 2021-12-16 Buy
AvaChem 2660A Esomeprazole 1g $119 2021-12-16 Buy
AvaChem 2660A Esomeprazole 10g $390 2021-12-16 Buy
Biorbyt Ltd orb134728 Esomeprazole >99% 100mg $414.8 2021-12-16 Buy
Biorbyt Ltd orb134728 Esomeprazole >99% 250mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb134728 Esomeprazole >99% 1g $1208.7 2021-12-16 Buy
Chemenu CM160492 (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole 97% 25g $262 2021-12-16 Buy

Properties

alpha :D20 -155° (c = 0.5 in chloroform)
Boiling point :600.0±60.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
form :A solid
pka :8.50±0.10(Predicted)
CAS DataBase Reference :119141-88-7(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P322 Specific measures (see …on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to..…

Description

Esomeprazole, formulated as a magnesium salt, reached the market as a treatment for acid-related diseases such as gastro-esophageal reflux (GERD) disease including peptic ulcer disease and reflux esophagitis. Esomeprazole (formerly perprazole) is the active (S)- enantiomer of omeprazole (1988) and the first proton pump inhibitor developed as an optical isomer. It can be obtained by several routes such as asymmetric oxidation of the pro-chiral pyridylmethyl benzimidazole sulfide, separation from the racemic sulfoxide by chiral chromatography or separation of a diastereomeric mixture obtained from the racemic compound and a chiral acid, followed by hydrolysis. Biochemical studies have shown that esomeprazole irreversibly inhibits the gastric H+/K+-adenosine triphosphatase (ATPase), an enzyme system involved at the secretory surface of the stomach’s parietal cells responsible for the secretion of gastric acid. Compared with racemic omeprazole in healthy subjects, esomeprazole has higher bioavailability, is absorbed more rapidly and exhibits a more uniform and predictable dose-response with higher plasma levels, leading to less inter-individual variability between slow and rapid metabolizers. In extensive clinical trials in patients suffering from GERD symptoms, esomeprazole provided superior acid control and significantly reduced the healing time compared to omeprazole.

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